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Journal of Medical Imaging • Open Access

Model predictions for the wide-angle x-ray scatter signals of healthy and malignant breast duct biopsies
Author(s): Robert J. LeClair; Andrew C. Ferreira; Nancy E. McDonald; Curtis Laamanen; Robert Yuan-zheng Tang

Paper Abstract

Wide-angle x-ray scatter (WAXS) could potentially be used to diagnose ductal carcinoma in situ (DCIS) in breast biopsies. The regions of interest were assumed to consist of fibroglandular tissue and epithelial cells and the model assumed that biopsies with DCIS would have a higher concentration of the latter. The scattered number of photons from a 2-mm diameter column of tissue was simulated using a 110-kV beam and selectively added in terms of momentum transfer. For a 1-min exposure, specificities and sensitivities of unity were obtained for biopsies 2- to 20-mm thick. The impact of sample and tumor cell layer thicknesses was studied. For example, a biopsy erroneously estimated to be 8 mm would be correctly diagnosed if its actual thickness was between 7.3 and 8.7 mm. An 8-mm thick malignant biopsy can be correctly diagnosed provided the malignant cell layer thickness is <0.96  mm. WAXS methods could become a diagnostic tool for DCIS within breast biopsies.

Paper Details

Date Published: 23 October 2015
PDF: 11 pages
J. Med. Imag. 2(4) 043502 doi: 10.1117/1.JMI.2.4.043502
Published in: Journal of Medical Imaging Volume 2, Issue 4
Show Author Affiliations
Robert J. LeClair, Laurentian Univ. (Canada)
Andrew C. Ferreira, Laurentian Univ. (Canada)
Nancy E. McDonald, Laurentian Univ. (Canada)
Curtis Laamanen, Laurentian Univ. (Canada)
Robert Yuan-zheng Tang, Laurentian Univ. (Canada)

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