Share Email Print

Journal of Medical Imaging

Experimental validation of L-shell x-ray fluorescence computed tomography imaging: phantom study
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Thanks to the current advances in nanoscience, molecular biochemistry, and x-ray detector technology, x-ray fluorescence computed tomography (XFCT) has been considered for molecular imaging of probes containing high atomic number elements, such as gold nanoparticles. The commonly used XFCT imaging performed with K-shell x rays appears to have insufficient imaging sensitivity to detect the low gold concentrations observed in small animal studies. Low energy fluorescence L-shell x rays have exhibited higher signal-to-background ratio and appeared as a promising XFCT mode with greatly enhanced sensitivity. The aim of this work was to experimentally demonstrate the feasibility of L-shell XFCT imaging and to assess its achievable sensitivity. We built an experimental L-shell XFCT imaging system consisting of a miniature x-ray tube and two spectrometers, a silicon drift detector (SDD), and a CdTe detector placed at ±120  deg with respect to the excitation beam. We imaged a 28-mm-diameter water phantom with 4-mm-diameter Eppendorf tubes containing gold solutions with concentrations of 0.06 to 0.1% Au. While all Au vials were detectable in the SDD L-shell XFCT image, none of the vials were visible in the CdTe L-shell XFCT image. The detectability limit of the presented L-shell XFCT SDD imaging setup was 0.007% Au, a concentration observed in small animal studies.

Paper Details

Date Published: 8 October 2015
PDF: 7 pages
J. Med. Imag. 2(4) 043501 doi: 10.1117/1.JMI.2.4.043501
Published in: Journal of Medical Imaging Volume 2, Issue 4
Show Author Affiliations
Magdalena Bazalova-Carter, Stanford Univ. (United States)
Univ. of Victoria (Canada)
Moiz Ahmad, Stanford Univ. (United States)
Lei Xing, Stanford Univ. (United States)
Rebecca Fahrig, Stanford Health Care (United States)

© SPIE. Terms of Use
Back to Top