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Journal of Medical Imaging

Associating spatial diversity features of radiologically defined tumor habitats with epidermal growth factor receptor driver status and 12-month survival in glioblastoma: methods and preliminary investigation
Author(s): Joonsang Lee; Shivali Narang; Juan J. Martinez; Ganesh Rao; Arvind U. K. Rao
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Paper Abstract

We analyzed the spatial diversity of tumor habitats, regions with distinctly different intensity characteristics of a tumor, using various measurements of habitat diversity within tumor regions. These features were then used for investigating the association with a 12-month survival status in glioblastoma (GBM) patients and for the identification of epidermal growth factor receptor (EGFR)-driven tumors. T1 postcontrast and T2 fluid attenuated inversion recovery images from 65 GBM patients were analyzed in this study. A total of 36 spatial diversity features were obtained based on pixel abundances within regions of interest. Performance in both the classification tasks was assessed using receiver operating characteristic (ROC) analysis. For association with 12-month overall survival, area under the ROC curve was 0.74 with confidence intervals [0.630 to 0.858]. The sensitivity and specificity at the optimal operating point (threshold=0.5) on the ROC were 0.59 and 0.75, respectively. For the identification of EGFR-driven tumors, the area under the ROC curve (AUC) was 0.85 with confidence intervals [0.750 to 0.945]. The sensitivity and specificity at the optimal operating point (threshold=0.166) on the ROC were 0.76 and 0.83, respectively. Our findings suggest that these spatial habitat diversity features are associated with these clinical characteristics and could be a useful prognostic tool for magnetic resonance imaging studies of patients with GBM.

Paper Details

Date Published: 25 August 2015
PDF: 9 pages
J. Med. Img. 2(4) 041006 doi: 10.1117/1.JMI.2.4.041006
Published in: Journal of Medical Imaging Volume 2, Issue 4
Show Author Affiliations
Joonsang Lee, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Shivali Narang, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Juan J. Martinez, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Ganesh Rao, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Arvind U. K. Rao, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


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