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Journal of Medical Imaging • Open Access

QuantitativeT2: interactive quantitative T2 MRI witnessed in mouse glioblastoma
Author(s): Tonima Sumya Ali; Thorarin Albert Bjarnason; Donna L. Senger; Jeffrey F. Dunn; Jeffery T. Joseph; Joseph Ross Mitchell

Paper Abstract

The aim of this study was to establish an advanced analytical platform for complex <italic<in vivo</italic< pathologies. We have developed a software program, QuantitativeT2, for voxel-based real-time quantitative T2 magnetic resonance imaging. We analyzed murine brain tumors to confirm feasibility of our method for neurological conditions. Anesthetized mice (with invasive gliomas, and controls) were imaged on a 9.4 Tesla scanner using a Carr–Purcell–Meiboom–Gill sequence. The multiecho T2 decays from axial brain slices were analyzed using QuantitativeT2. T2 distribution histograms demonstrated substantial characteristic differences between normal and pathological brain tissues. Voxel-based quantitative maps of tissue water fraction (WF) and geometric mean T2 (gmT2) revealed the heterogeneous alterations to water compartmentalization caused by pathology. The numeric distribution of WF and gmT2 indicated the extent of tumor infiltration. Relative evaluations between <italic<in vivo</italic< scans and <italic<ex vivo</italic< histology indicated that the T2s between 30 and 150 ms were related to cellular density and the integrity of the extracellular matrix. Overall, QuantitativeT2 has demonstrated significant advancements in qT2 analysis with real-time operation. It is interactive with an intuitive workflow; can analyze data from many MR manufacturers; and is released as open-source code to encourage examination, improvement, and expansion of this method.

Paper Details

Date Published: 21 July 2015
PDF: 12 pages
J. Med. Img. 2(3) 036002 doi: 10.1117/1.JMI.2.3.036002
Published in: Journal of Medical Imaging Volume 2, Issue 3
Show Author Affiliations
Tonima Sumya Ali, Queensland Univ. of Technology (Australia)
Thorarin Albert Bjarnason, Diagnostic Imaging Services (Canada)
Univ. of British Columbia (Canada)
Univ. of British Columbia Okanagan (Canada)
Donna L. Senger, Univ. of Calgary (Canada)
Jeffrey F. Dunn, Univ. of Calgary (Canada)
Jeffery T. Joseph, Foothills Medical Ctr. (Canada)
Joseph Ross Mitchell, Mayo Clinic (United States)

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