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Journal of Medical Imaging

Fiber orientation measurements by diffusion tensor imaging improve hydrogen-1 magnetic resonance spectroscopy of intramyocellular lipids in human leg muscles
Author(s): Sunil K. Valaparla; Feng Gao; Giuseppe Daniele; Muhammad Abdul-Ghani; Geoffrey D. Clarke
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Paper Abstract

Twelve healthy subjects underwent hydrogen-1 magnetic resonance spectroscopy (1H-MRS) acquisition (15×15×15  mm3), diffusion tensor imaging (DTI) with a b-value of 600  s mm−2, and fat-water magnetic resonance imaging (MRI) using the Dixon method. Subject-specific muscle fiber orientation, derived from DTI, was used to estimate the lipid proton spectral chemical shift. Pennation angles were measured as 23.78 deg in vastus lateralis (VL), 17.06 deg in soleus (SO), and 8.49 deg in tibialis anterior (TA) resulting in a chemical shift between extramyocellular lipids (EMCL) and intramyocellular lipids (IMCL) of 0.15, 0.17, and 0.19 ppm, respectively. IMCL concentrations were 8.66±1.24  mmol kg−1, 6.12±0.77  mmol kg−1, and 2.33±0.19  mmol kg−1 in SO, VL, and TA, respectively. Significant differences were observed in IMCL and EMCL pairwise comparisons in SO, VL, and TA (p<0.05). Strong correlations were observed between total fat fractions from 1H-MRS and Dixon MRI for VL (r=0.794), SO (r=0.655), and TA (r=0.897). Bland-Altman analysis between fat fractions (FFMRS and FFMRI) showed good agreement with small limits of agreement (LoA): bias=−0.21% (LoA: −1.12% to 0.69%) in VL, bias=0.025% (LoA: −1.28% to 1.33%) in SO, and bias=−0.13% (LoA: −0.74% to 0.47%) in TA. The results of this study demonstrate the variation in muscle fiber orientation and lipid concentrations in these three skeletal muscle types.

Paper Details

Date Published: 9 June 2015
PDF: 9 pages
J. Med. Img. 2(2) 026002 doi: 10.1117/1.JMI.2.2.026002
Published in: Journal of Medical Imaging Volume 2, Issue 2
Show Author Affiliations
Sunil K. Valaparla, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Feng Gao, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Giuseppe Daniele, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Univ. di Pisa (Italy)
Muhammad Abdul-Ghani, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Geoffrey D. Clarke, The Univ. of Texas Health Science Ctr. at San Antonio (United States)


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