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Journal of Medical Imaging

Parametric ultrasound and fluoroscopy image fusion for guidance of left ventricle lead placement in cardiac resynchronization therapy
Author(s): Aleksandar Babic; Hans Henrik Odland; Olivier Gérard; Eigil Samset
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Paper Abstract

Recent studies show that the response rate to cardiac resynchronization therapy (CRT) could be improved if the left ventricle (LV) is paced at the site of the latest mechanical activation, but away from the myocardial scar. A prototype system for CRT lead placement guidance that combines LV functional information from ultrasound with live x-ray fluoroscopy was developed. Two mean anatomical models, each containing LV epi-, LV endo- and right ventricle endocardial surfaces, were computed from a database of 33 heart failure patients as a substitute for a patient-specific model. The sphericity index was used to divide the observed population into two groups. The distance between the mean and the patient-specific models was determined using a signed distance field metric (reported in mm). The average error values for LV epicardium were −0.4±4.6 and for LV endocardium were −0.3±4.4. The validity of using average LV models for a CRT procedure was tested by simulating coronary vein selection in a group of 15 CRT candidates. The probability of selecting the same coronary branch, when basing the selection on the average model compared to a patient-specific model, was estimated to be 95.3±2.9%. This was found to be clinically acceptable.

Paper Details

Date Published: 13 May 2015
PDF: 7 pages
J. Med. Imag. 2(2) 025001 doi: 10.1117/1.JMI.2.2.025001
Published in: Journal of Medical Imaging Volume 2, Issue 2
Show Author Affiliations
Aleksandar Babic, Oslo Univ. Hospital (Norway)
GE Vingmed Ultrasound AS (Norway)
Hans Henrik Odland, Oslo Univ. Hospital (Norway)
Olivier Gérard, GE Vingmed Ultrasound AS (Norway)
Eigil Samset, Univ. I Oslo (Norway)
GE Vingmed Ultrasound AS (Norway)

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