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Journal of Medical Imaging • Open Access

Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography
Author(s): Madhusudhana Gargesha; Ronny Shalev; David Prabhu; Kentaro Tanaka; Andrew M. Rollins; Marco Costa; Hiram G. Bezerra; David L. Wilson

Paper Abstract

We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation μt and backscattered intensity I0 from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual line methods, root mean square error was the best goodness-of-fit, and α-trimmed PL (α-T-PL) was the best overall method. Estimates of μt were calcified (3.84 ± 0.95  mm1), fibrotic (2.15 ± 1.08  mm1), and lipid (9.99 ± 2.37  mm1), similar to those in the literature, and tissue classification from optical properties alone was promising.

Paper Details

Date Published: 2 January 2015
PDF: 14 pages
J. Med. Img. 2(1) 016001 doi: 10.1117/1.JMI.2.1.016001
Published in: Journal of Medical Imaging Volume 2, Issue 1
Show Author Affiliations
Madhusudhana Gargesha, Case Western Reserve Univ. (United States)
Ronny Shalev, Case Western Reserve Univ. (United States)
David Prabhu, Case Western Reserve Univ. (United States)
Kentaro Tanaka, Univ. Hospitals Case Medical Ctr. (United States)
Andrew M. Rollins, Case Western Reserve Univ. (United States)
Marco Costa, Univ. Hospitals Case Medical Ctr. (United States)
Hiram G. Bezerra, Univ. Hospitals Case Medical Ctr. (United States)
David L. Wilson, Case Western Reserve Univ. (United States)


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