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Journal of Medical Imaging

Structured learning algorithm for detection of nonobstructive and obstructive coronary plaque lesions from computed tomography angiography
Author(s): Dongwoo Kang; Damini Dey; Piotr J. Slomka; Reza Arsanjani; Ryo Nakazato; Hyunsuk Ko; Daniel S. Berman; Debiao Li; C. C. Jay Kuo
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Paper Abstract

Visual identification of coronary arterial lesion from three-dimensional coronary computed tomography angiography (CTA) remains challenging. We aimed to develop a robust automated algorithm for computer detection of coronary artery lesions by machine learning techniques. A structured learning technique is proposed to detect all coronary arterial lesions with stenosis ≥25%. Our algorithm consists of two stages: (1) two independent base decisions indicating the existence of lesions in each arterial segment and (b) the final decision made by combining the base decisions. One of the base decisions is the support vector machine (SVM) based learning algorithm, which divides each artery into small volume patches and integrates several quantitative geometric and shape features for arterial lesions in each small volume patch by SVM algorithm. The other base decision is the formula-based analytic method. The final decision in the first stage applies SVM-based decision fusion to combine the two base decisions in the second stage. The proposed algorithm was applied to 42 CTA patient datasets, acquired with dual-source CT, where 21 datasets had 45 lesions with stenosis ≥25%. Visual identification of lesions with stenosis ≥25% by three expert readers, using consensus reading, was considered as a reference standard. Our method performed with high sensitivity (93%), specificity (95%), and accuracy (94%), with receiver operator characteristic area under the curve of 0.94. The proposed algorithm shows promising results in the automated detection of obstructive and nonobstructive lesions from CTA.

Paper Details

Date Published: 6 March 2015
PDF: 9 pages
J. Med. Img. 2(1) 014003 doi: 10.1117/1.JMI.2.1.014003
Published in: Journal of Medical Imaging Volume 2, Issue 1
Show Author Affiliations
Dongwoo Kang, The Univ. of Southern California (United States)
Damini Dey, Cedars-Sinai Medical Ctr. (United States)
Piotr J. Slomka, Cedars-Sinai Medical Ctr. (United States)
Reza Arsanjani, Cedars-Sinai Medical Ctr. (United States)
Ryo Nakazato, Cedars-Sinai Medical Ctr. (United States)
Hyunsuk Ko, The Univ. of Southern California (United States)
Daniel S. Berman, Cedars-Sinai Medical Ctr. (United States)
Debiao Li, Cedars-Sinai Medical Ctr. (United States)
C. C. Jay Kuo, The Univ. of Southern California (United States)


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