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Journal of Medical Imaging

Optimization of contrast-enhanced spectral mammography depending on clinical indication
Author(s): Clarisse Dromain; Sandra Canale; Sylvie Saab-Puong; Ann-Katherine Carton; Serge L. Muller; Eva Maria Fallenberg
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Paper Abstract

The objective is to optimize low-energy (LE) and high-energy (HE) exposure parameters of contrast-enhanced spectral mammography (CESM) examinations in four different clinical applications for which different levels of average glandular dose (AGD) and ratios between LE and total doses are required. The optimization was performed on a Senographe DS with a SenoBright® upgrade. Simulations were performed to find the optima by maximizing the contrast-to-noise ratio (CNR) on the recombined CESM image using different targeted doses and LE image quality. The linearity between iodine concentration and CNR as well as the minimal detectable iodine concentration was assessed. The image quality of the LE image was assessed on the CDMAM contrast-detail phantom. Experiments confirmed the optima found on simulation. The CNR was higher for each clinical indication than for SenoBright®, including the screening indication for which the total AGD was 22% lower. Minimal iodine concentrations detectable in the case of a 3-mm-diameter round tumor were 12.5% lower than those obtained for the same dose in the clinical routine. LE image quality satisfied EUREF acceptable limits for threshold contrast. This newly optimized set of acquisition parameters allows increased contrast detectability compared to parameters currently used without a significant loss in LE image quality.

Paper Details

Date Published: 30 December 2014
PDF: 11 pages
J. Med. Imag. 1(3) 033506 doi: 10.1117/1.JMI.1.3.033506
Published in: Journal of Medical Imaging Volume 1, Issue 3
Show Author Affiliations
Clarisse Dromain, Institut Gustave Roussy (France)
Sandra Canale, Institut Gustave Roussy (France)
Sylvie Saab-Puong, GE Healthcare France (France)
Ann-Katherine Carton, GE Healthcare France (France)
Serge L. Muller, GE Healthcare France (France)
Eva Maria Fallenberg, Charité Universitätsmedizin Berlin (Germany)

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