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Journal of Biomedical Optics

Optical coherence tomography for the diagnosis of malignant skin tumors: a meta-analysis
Author(s): Yi-Quan Xiong; Yun Mo; Yu-Qi Wen; Ming-Ji Cheng; Shu-Ting Huo; Xue-Jiao Chen; Qing Chen
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Paper Abstract

Optical coherence tomography (OCT) is an emergent imaging tool used for noninvasive diagnosis of skin diseases. The present meta-analysis was carried out to assess the accuracy of OCT for the diagnosis of skin cancer. We conducted a systematic literature search though EMBASE, Medline, PubMed, the Cochrane Library, and Web of Science database for relevant articles published up to June 6, 2017. The quality of the included studies was assessed using the QUADAS-2 tool and the Oxford Levels of Evidence Scale. Statistical analyses were conducted using the software Meta-Disc version 1.4 and STATA version 12.0. A total of 14 studies involving more than 813 patients with a total of 1958 lesions were included in our analyses. The pooled sensitivity and specificity of OCT for skin cancer diagnoses were 91.8% and 86.7%, respectively. Subgroup analysis showed that the pooled sensitivities of OCT for detecting basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratosis, and malignant melanoma were 92.4%, 92.3%, 73.8%, and 81.0%, respectively. The pooled specificities were 86.9%, 99.5%, 91.5%, and 93.8%, respectively. OCT appears to be useful for the detection of BCC and SCC. It is a valuable diagnostic method when screening for early skin cancers.

Paper Details

Date Published: 22 February 2018
PDF: 10 pages
J. Biomed. Opt. 23(2) 020902 doi: 10.1117/1.JBO.23.2.020902
Published in: Journal of Biomedical Optics Volume 23, Issue 2
Show Author Affiliations
Yi-Quan Xiong, Southern Medical Univ. (China)
Yun Mo, Southern Medical Univ. (China)
Yu-Qi Wen, Southern Medical Univ. (China)
Ming-Ji Cheng, Southern Medical Univ. (China)
Shu-Ting Huo, Southern Medical Univ. (China)
Xue-Jiao Chen, Southern Medical Univ. (China)
Qing Chen, Southern Medical Univ. (China)


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