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Journal of Biomedical Optics • Open Access

Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses
Author(s): Yan Liu; Yuecheng Shen; Haowen Ruan; Frank L. Brodie; Terence T. W. Wong; Changhuei Yang; Lihong V. Wang

Paper Abstract

Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications, which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded optical focusing in reflection mode, we focused 532-nm light through a highly scattering ex vivo adult human cataractous lens. This work demonstrates a potential clinical application of wavefront shaping techniques.

Paper Details

Date Published: 10 January 2018
PDF: 4 pages
J. Biomed. Opt. 23(1) 010501 doi: 10.1117/1.JBO.23.1.010501
Published in: Journal of Biomedical Optics Volume 23, Issue 1
Show Author Affiliations
Yan Liu, Caltech (United States)
Yuecheng Shen, Caltech (United States)
Haowen Ruan, Caltech (United States)
Frank L. Brodie, Univ. of California, San Francisco (United States)
Terence T. W. Wong, Caltech (United States)
Changhuei Yang, Caltech (United States)
Lihong V. Wang, Caltech (United States)

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