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Journal of Biomedical Optics

Luminescent diagnostics of skin defects in the near-infrared range
Author(s): Yuri V. Alekseev; Valentina D. Rumyantseva; Anastasiya S. Gorshkova; Anastasiya E. Shchelkunova; Igor P. Shilov; Andrey V. Ivanov
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Paper Abstract

Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine.

Paper Details

Date Published: 15 September 2017
PDF: 7 pages
J. Biomed. Opt. 22(9) 098001 doi: 10.1117/1.JBO.22.9.098001
Published in: Journal of Biomedical Optics Volume 22, Issue 9
Show Author Affiliations
Yuri V. Alekseev, State Scientific Ctr. of Laser Medicine (Russia)
Valentina D. Rumyantseva, Moscow Technological Univ. (Russia)
Kotel’nikov Institute of Radioengineering and Electronics RAS (Russia)
Anastasiya S. Gorshkova, Moscow Technological Univ. (Russia)
Anastasiya E. Shchelkunova, Moscow Technological Univ. (Russia)
Igor P. Shilov, Kotel'nikov Institute of Radio Engineering and Electronics, RAS (Russian Federation)
Andrey V. Ivanov, State Scientific Ctr. of Laser Medicine FMBA, Moscow (Russia)
Blokhin Cancer Research Ctr. (Russia)

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