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Journal of Biomedical Optics • new

Linearly chirped fiber Bragg grating response to thermal gradient: from bench tests to the real-time assessment during <italic<in vivo</italic< laser ablations of biological tissue
Author(s): Paola Saccomandi; Ambra Varalda; Riccardo Gassino; Daniele Tosi; Carlo Massaroni; Michele A. Caponero; Raoul Pop; Sanzhar Korganbayev; Guido Perrone; Michele Diana; Alberto Vallan; Guido Costamagna; Jacques Marescaux; Emiliano Schena
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Paper Abstract

The response of a fiber optic sensor [linearly chirped fiber Bragg grating (LCFBG)] to a linear thermal gradient applied on its sensing length (i.e., 1.5 cm) has been investigated. After these bench tests, we assessed their feasibility for temperature monitoring during thermal tumor treatment. In particular, we performed experiments during <italic<ex vivo</italic< laser ablation (LA) in pig liver and <italic<in vivo</italic< thermal ablation in animal models (pigs). We investigated the following: (i) the relationship between the full width at half maximum of the LCFBG spectrum and the temperature difference among the extremities of the LCFBG and (ii) the relationship between the mean spectrum wavelength and the mean temperature acting on the LCFBG sensing area. These relationships showed a linear trend during both bench tests and LA in animal models. Thermal sensitivity was significant although different values were found with regards to bench tests and animal experiments. The linear trend and significant sensitivity allow hypothesizing a future use of this kind of sensor to monitor both temperature gradient and mean temperature within a tissue undergoing thermal treatment.

Paper Details

Date Published: 14 September 2017
PDF: 9 pages
J. Biomed. Opt. 22(9) 097002 doi: 10.1117/1.JBO.22.9.097002
Published in: Journal of Biomedical Optics Volume 22, Issue 9
Show Author Affiliations
Paola Saccomandi, IHU Strasbourg - Institute of Image-Guided Surgery (France)
Univ. Campus Bio-Medico (Italy)
Ambra Varalda, Univ. Campus Bio-Medico (Italy)
Riccardo Gassino, Politecnico di Torino (Italy)
Daniele Tosi, Nazarbayev Univ. (Kazakhstan)
Carlo Massaroni, Univ. Campus Bio-Medico (Italy)
Michele A. Caponero, ENEA (Italy)
Raoul Pop, CHRU-Ctr. Hospitalier Régional et Univ. (France)
Sanzhar Korganbayev, Nazarbayev Univ. (Kazakhstan)
Guido Perrone, Politecnico di Torino (Italy)
Michele Diana, IHU-Strasbourg - Institute of Image-Guided Surgery (France)
Institut de Recherche Contre les Cancers de L'Appareil Digestif (France)
Alberto Vallan, Politecnico di Torino (Italy)
Guido Costamagna, IHU-Strasbourg - Institute of Image-Guided Surgery, Strasbourg (France)
Univ. Cattolica del Sacro Cuore (Italy)
Jacques Marescaux, IHU Strasbourg-Institute of Image-Guided Surgery (France)
IRCAD (France)
Emiliano Schena, Univ. Campus Bio-Medico (Italy)

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