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Journal of Biomedical Optics • Open Access • new

Tissue characterization with depth-resolved attenuation coefficient and backscatter term in intravascular optical coherence tomography images
Author(s): Shengnan Liu; Yohei Sotomi; Jeroen Eggermont; Gaku Nakazawa; Sho Torii; Takeshi Ijichi; Yoshinobu Onuma; Patrick W. Serruys; Boudewijn P. F. Lelieveldt; Jouke Dijkstra

Paper Abstract

An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation. In order to exclude noisy regions with a weak signal, an automated algorithm is implemented to determine the cut-off border in IVOCT images. The attenuation coefficient, backscatter term, and the image intensity are further analyzed in regions of interest, which have been delineated referring to their pathology counterparts. Local statistical values were reported and their distributions were further compared with a two-sample t-test to evaluate the potential for distinguishing six types of tissues. Results show that the IVOCT intensity, DR attenuation coefficient, and backscatter term extracted with the reported implementation are complementary to each other on characterizing six tissue types: mixed, calcification, fibrous, lipid-rich, macrophages, and necrotic core.

Paper Details

Date Published: 12 September 2017
PDF: 16 pages
J. Biomed. Opt. 22(9) 096004 doi: 10.1117/1.JBO.22.9.096004
Published in: Journal of Biomedical Optics Volume 22, Issue 9
Show Author Affiliations
Shengnan Liu, Leiden Univ. Medical Ctr. (The Netherlands)
Yohei Sotomi, Academisch Medisch Centrum (The Netherlands)
Jeroen Eggermont, Leiden Univ. Medical Ctr. (The Netherlands)
Gaku Nakazawa, Tokai Univ. School of Medicine (Japan)
Sho Torii, Tokai Univ. School of Medicine (Japan)
Takeshi Ijichi, Tokai Univ. School of Medicine (Japan)
Yoshinobu Onuma, Cardialysis B.V. (The Netherlands)
Erasmus MC (The Netherlands)
Patrick W. Serruys, Erasmus MC (United Kingdom)
Boudewijn P. F. Lelieveldt, Leiden Univ. Medical Ctr. (The Netherlands)
Technische Univ. Delft (The Netherlands)
Jouke Dijkstra, Leiden Univ. Medical Ctr. (The Netherlands)

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