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Journal of Biomedical Optics • new

Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing
Author(s): Emil Sobol; Olga Baum; Anatoly Shekhter; Sebastian Wachsmann-Hogiu; Alexander Shnirelman; Yulia Alexandrovskaya; Ivan Sadovskyy; Valerii Vinokur
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Paper Abstract

Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

Paper Details

Date Published: 31 May 2017
PDF: 10 pages
J. Biomed. Opt. 22(9) 091515 doi: 10.1117/1.JBO.22.9.091515
Published in: Journal of Biomedical Optics Volume 22, Issue 9
Show Author Affiliations
Emil Sobol, Institute on Laser and Information Technologies (Russian Federation)
FNITS "Crystallography and photonics" RAS. (Russia)
Olga Baum, FNITS "Crystallography and photonics" RAS (Russia)
Anatoly Shekhter, I.M. Sechenov Moscow Medical Academy (Russia)
Sebastian Wachsmann-Hogiu, Univ. of California (United States)
McGill Univ. (Canada)
Alexander Shnirelman, Concordia Univ. (Canada)
Yulia Alexandrovskaya, Institute of Applied Physics of the Russian Academy of Sciences (Russian Federation)
FNITS "Crystallography and photonics" RAS (Russia)
Ivan Sadovskyy, Argonne National Lab. (United States)
Valerii Vinokur, Argonne National Lab. (United States)

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