Share Email Print
cover

Journal of Biomedical Optics

Protease sensing using nontoxic silicon quantum dots
Author(s): Xiaoyu Cheng; Benjamin F. P. McVey; Andrew B. Robinson; Guillaume Longatte; Peter B. O’Mara; Vincent T. G. Tan; Pall Thordarson; Richard D. Tilley; Katharina Gaus; J. Justin Gooding
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

Herein is presented a proof-of-concept study of protease sensing that combines nontoxic silicon quantum dots (SiQDs) with Förster resonance energy transfer (FRET). The SiQDs serve as the donor and an organic dye as the acceptor. The dye is covalently attached to the SiQDs using a peptide linker. Enzymatic cleavage of the peptide leads to changes in FRET efficiency. The combination of interfacial design and optical imaging presented in this work opens opportunities for use of nontoxic SiQDs relevant to intracellular sensing and imaging.

Paper Details

Date Published: 23 August 2017
PDF: 7 pages
J. Biomed. Opt. 22(8) 087002 doi: 10.1117/1.JBO.22.8.087002
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Xiaoyu Cheng, The Univ. of New South Wales (Australia)
Benjamin F. P. McVey, The Univ. of New South Wales (Australia)
Andrew B. Robinson, The Univ. of New South Wales (Australia)
Guillaume Longatte, The Univ. of New South Wales (Australia)
Peter B. O’Mara, The Univ. of New South Wales (Australia)
Vincent T. G. Tan, The Univ. of New South Wales (Australia)
Pall Thordarson, The Univ. of New South Wales (Australia)
Richard D. Tilley, The Univ. of New South Wales (Australia)
Katharina Gaus, The Univ. of New South Wales (Australia)
J. Justin Gooding, The Univ. of New South Wales (Australia)


© SPIE. Terms of Use
Back to Top