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Journal of Biomedical Optics

Use of Mueller matrix polarimetry and optical coherence tomography in the characterization of cervical collagen anisotropy
Author(s): Joseph Chue-Sang; Yuqiang Bai; Susan Stoff; Mariacarla Gonzalez; Nola A. Holness; Jefferson Gomes; Ranu Jung; Amir H. Gandjbakhche; Viktor V. Chernomordik; Jessica C. Ramella-Roman
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Paper Abstract

Preterm birth (PTB) presents a serious medical health concern throughout the world. There is a high incidence of PTB in both developed and developing countries ranging from 11% to 15%, respectively. Recent research has shown that cervical collagen orientation and distribution changes during pregnancy may be useful in predicting PTB. Polarization imaging is an effective means to measure optical anisotropy in birefringent materials, such as the cervix’s extracellular matrix. Noninvasive, full-field Mueller matrix polarimetry (MMP) imaging methodologies, and optical coherence tomography (OCT) imaging were used to assess cervical collagen content and structure in nonpregnant porcine cervices. We demonstrate that the highly ordered structure of the nonpregnant porcine cervix can be observed with MMP. Furthermore, when utilized

Paper Details

Date Published: 29 August 2017
PDF: 9 pages
J. Biomed. Opt. 22(8) 086010 doi: 10.1117/1.JBO.22.8.086010
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Joseph Chue-Sang, Florida International Univ. (United States)
Yuqiang Bai, Florida International Univ. (United States)
Susan Stoff, Florida International Univ. (United States)
Mariacarla Gonzalez, Florida International Univ. (United States)
Nola A. Holness, Florida International Univ. (United States)
Jefferson Gomes, Florida International Univ. (United States)
Ranu Jung, Florida International Univ. (United States)
Amir H. Gandjbakhche, National Institutes of Health (United States)
Viktor V. Chernomordik, National Institutes of Health (United States)
Jessica C. Ramella-Roman, Florida International Univ. (United States)

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