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Journal of Biomedical Optics

Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study
Author(s): Nico Bodenschatz; Catherine F. Poh; Sylvia Lam; Pierre M. Lane; Martial Guillaud; Calum E. MacAulay
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Paper Abstract

Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo.

Paper Details

Date Published: 19 August 2017
PDF: 10 pages
J. Biomed. Opt. 22(8) 086005 doi: 10.1117/1.JBO.22.8.086005
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Nico Bodenschatz, BC Cancer Research Ctr. (Canada)
Catherine F. Poh, BC Cancer Research Ctr. (Canada)
The Univ. of British Columbia (Canada)
Sylvia Lam, BC Cancer Research Ctr. (Canada)
Pierre M. Lane, BC Cancer Research Ctr. (Canada)
Martial Guillaud, BC Cancer Research Ctr. (Canada)
Calum E. MacAulay, BC Cancer Research Ctr. (Canada)

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