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Journal of Biomedical Optics

Quantitative attenuation analysis for identification of early Barrett’s neoplasia in volumetric laser endomicroscopy
Author(s): Anne-Fré Swager; Dirk J. Faber; Daniel Martijn de Bruin; Bas Lam Weusten; Sybren L. Meijer; Jacques Bergman; Wouter L. Curvers; Ton G. van Leeuwen
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Paper Abstract

Early neoplasia in Barrett’s esophagus (BE) is difficult to detect. Volumetric laser endomicroscopy (VLE) incorporates optical coherence tomography, providing a circumferential scan of the esophageal wall layers. The attenuation coefficient (μVLE) quantifies decay of detected backscattered light versus depth, and could potentially improve BE neoplasia detection. The aim is to investigate feasibility of μVLE for identification of early BE neoplasia. In vivo and ex vivo VLE scans with histological correlation from BE patients ± neoplasia were used. Quantification by μVLE was performed manually on areas of interest (AoIs) to differentiate neoplasia from nondysplastic (ND)BE. From ex vivo VLE scans from 16 patients (13 with neoplasia), 68 AoIs were analyzed. Median μVLE values (mm−1) were 3.7 [2.1 to 4.4 interquartile range (IQR)] for NDBE and 4.0 (2.5 to 4.9 IQR) for neoplasia, not statistically different (p=0.82). Fourteen in vivo scans were used: nine from neoplastic and five from NDBE patients. Median μVLE values were 1.8 (1.5 to 2.6 IQR) for NDBE and 2.1 (1.9 to 2.6 IQR) for neoplasia, with no statistically significant difference (p=0.37). In conclusion, there was no significant difference in μVLE values in VLE scans from early neoplasia versus NDBE. Future studies with a larger sample size should explore other quantitative methods for detection of neoplasia during BE surveillance.

Paper Details

Date Published: 4 August 2017
PDF: 9 pages
J. Biomed. Opt. 22(8) 086001 doi: 10.1117/1.JBO.22.8.086001
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Anne-Fré Swager, Academisch Medisch Centrum (The Netherlands)
Dirk J. Faber, Academisch Medisch Centrum (Netherlands)
Daniel Martijn de Bruin, Academisch Medisch Centrum (The Netherlands)
Bas Lam Weusten, Academisch Medisch Centrum (Netherlands)
Sybren L. Meijer, Academisch Medisch Centrum (The Netherlands)
Jacques Bergman, Academisch Medisch Centrum (Netherlands)
Wouter L. Curvers, Catharina Hospital (The Netherlands)
Ton G. van Leeuwen, Academisch Medisch Centrum (The Netherlands)

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