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Journal of Biomedical Optics • Open Access

Miniaturized pulsed laser source for time-domain diffuse optics routes to wearable devices
Author(s): Laura Di Sieno; Jan Nissinen; Lauri Hallman; Edoardo Martinenghi; Davide Contini; Antonio Pifferi; Juha Kostamovaara; Alberto D. Mora

Paper Abstract

We validate a miniaturized pulsed laser source for use in time-domain (TD) diffuse optics, following rigorous and shared protocols for performance assessment of this class of devices. This compact source (12×6  mm2) has been previously developed for range finding applications and is able to provide short, high energy (∼100  ps, ∼0.5  nJ) optical pulses at up to 1 MHz repetition rate. Here, we start with a basic level laser characterization with an analysis of suitability of this laser for the diffuse optics application. Then, we present a TD optical system using this source and its performances in both recovering optical properties of tissue-mimicking homogeneous phantoms and in detecting localized absorption perturbations. Finally, as a proof of concept of in vivo application, we demonstrate that the system is able to detect hemodynamic changes occurring in the arm of healthy volunteers during a venous occlusion. Squeezing the laser source in a small footprint removes a key technological bottleneck that has hampered so far the realization of a miniaturized TD diffuse optics system, able to compete with already assessed continuous-wave devices in terms of size and cost, but with wider performance potentialities, as demonstrated by research over the last two decades.

Paper Details

Date Published: 19 August 2017
PDF: 9 pages
J. Biomed. Opt. 22(8) 085004 doi: 10.1117/1.JBO.22.8.085004
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Laura Di Sieno, Politecnico di Milano (Italy)
Jan Nissinen, Univ. of Oulu (Finland)
Lauri Hallman, Univ. of Oulu (Finland)
Edoardo Martinenghi, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Consiglio Nazionale delle Ricerche (Italy)
Juha Kostamovaara, Univ. of Oulu (Finland)
Alberto D. Mora, Politecnico di Milano (Italy)

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