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Journal of Biomedical Optics

Measurement of tissue-radiation dosage using a thermal steady-state elastic shear wave
Author(s): Sheng-Yi Chang; Tong-Sheng Hsieh; Wei-Ru Chen; Jin-Chung Chen; Chien Chou
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Paper Abstract

A biodosimeter based on thermal-induced elastic shear wave (TIESW) in silicone acellular porcine dermis (SAPD) at thermal steady state has been proposed and demonstrated. A square slab SAPD treated with ionizing radiation was tested. The SAPD becomes a continuous homogeneous and isotropic viscoelastic medium due to the generation of randomly coiled collagen fibers formed from their bundle-like structure in the dermis. A harmonic TIESW then propagates on the surface of the SAPD as measured by a nanometer-scaled strain-stress response under thermal equilibrium conditions at room temperature. TIESW oscillation frequency was noninvasively measured in real time by monitoring the transverse displacement of the TIESW on the SAPD surface. Because the elastic shear modulus is highly sensitive to absorbed doses of ionizing radiation, this proposed biodosimeter can become a highly sensitive and noninvasive method for quantitatively determining tissue-absorbed dosage in terms of TIESW’s oscillation frequency. Detection sensitivity at 1 cGy and dynamic ranges covering 1 to 40 cGy and 80 to 500 cGy were demonstrated.

Paper Details

Date Published: 4 August 2017
PDF: 8 pages
J. Biomed. Opt. 22(8) 085001 doi: 10.1117/1.JBO.22.8.085001
Published in: Journal of Biomedical Optics Volume 22, Issue 8
Show Author Affiliations
Sheng-Yi Chang, Chang Gung Univ. (Taiwan)
Ming Chi Univ. of Technology (Taiwan)
Tong-Sheng Hsieh, Taipei Veterans General Hospital (Taiwan)
Wei-Ru Chen, Chang Gung Univ. (Taiwan)
Jin-Chung Chen, Chang Gung Univ. (Taiwan)
Chien Chou, Chang Gung Univ. (Taiwan)

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