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Journal of Biomedical Optics • new

Floating reference position-based correction method for near-infrared spectroscopy in long-term glucose concentration monitoring
Author(s): Guang Han; Tongshuai Han; Kexin Xu; Jin Liu
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Paper Abstract

We present a floating reference position (FRP)-based drift correction method for near-infrared (NIR) spectroscopy-based long-term blood glucose concentration (BGC) monitoring. Previously, we reported that it is difficult to quantify the systematic drift caused by the fluctuation of incident light intensity at different source–detector (SD) separations based on the absolute FRP change. We use the relative FRP change as a baseline reference to quantitatively characterize the signal drift at different SD separations. For the wavelengths that were used, a uniform equation was developed to describe the relationship between the drift and the relative FRP change. With the help of this equation, the correction can easily be performed by subtracting the systematic drift estimated by the equation. A theoretical analysis and an experimental phantom study demonstrated that our method could be used for systematic drift correction in NIR spectroscopy for long-term BGC monitoring. Moreover, the analysis method can also be referenced to reduce drifts from multiple sources.

Paper Details

Date Published: 5 July 2017
PDF: 8 pages
J. Biomed. Opt. 22(7) 077001 doi: 10.1117/1.JBO.22.7.077001
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Guang Han, Tianjin Univ. (China)
Tongshuai Han, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)
Jin Liu, Tianjin Univ. (China)


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