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Journal of Biomedical Optics

Modulation of ultrasound-switchable fluorescence for improving signal-to-noise ratio
Author(s): Jayanth Kandukuri; Shuai Yu; Tingfeng Yao; Baohong Yuan
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Paper Abstract

Simultaneously achieving high signal-to-noise ratio (SNR) (or sensitivity) and high resolution is desired in biomedical imaging. However, conventional imaging modality has a tradeoff between SNR (or sensitivity) and resolution. We developed a method to simultaneously achieve high SNR (or sensitivity) and high resolution for fluorescence imaging in deep tissue. We first introduce a recently developed deep-tissue high-resolution imaging technique termed as ultrasound-switchable fluorescence (USF). An approach of modulating ultrasound exposure time is adopted to increase the detectability of the USF signal. The control parameters of modulation of ultrasound—such as (1) frequency, (2) duty cycle, and (3) exposure duration—are varied to study their influence on the USF signal and SNR. We conclude that high SNR can be achieved by modulating ultrasound exposure without sacrificing the spatial resolution. This is important for future fluorescence molecular imaging of cancer in deep tissue.

Paper Details

Date Published: 31 July 2017
PDF: 9 pages
J. Biomed. Opt. 22(7) 076021 doi: 10.1117/1.JBO.22.7.076021
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Jayanth Kandukuri, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr at Dallas (United States)
Shuai Yu, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr at Dallas (United States)
Tingfeng Yao, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr at Dallas (United States)
Baohong Yuan, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr at Dallas (United States)


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