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Journal of Biomedical Optics • new

Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography
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Paper Abstract

Based on the photoacoustic (PA) effect, PA tomography directly measures specific optical absorption, i.e., absorbed optical energy per unit volume. We recently developed a full-ring ultrasonic transducer array-based photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The system has a full-view detection angle and high in-plane resolution (∼100  μm). However, due to the bandpass frequency response of the piezoelectric transducer elements and the limited elevational detection coverage of the full-ring transducer array, the reconstructed images present bipolar (i.e., both positive and negative) pixel values, which cause ambiguities in image interpretation for physicians and biologists. We propose a multiview Hilbert transformation method to recover the unipolar initial pressure for full-ring PACT. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with ex vivo mouse brain structural imaging and in vivo mouse whole-body imaging.

Paper Details

Date Published: 26 July 2017
PDF: 7 pages
J. Biomed. Opt. 22(7) 076017 doi: 10.1117/1.JBO.22.7.076017
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Lei Li, Washington Univ. in St. Louis (United States)
California Institute of Technology (United States)
Liren Zhu, California Institute of Technology (United States)
Washington Univ. in St. Louis (United States)
Yuecheng Shen, California Institute of Technology (United States)
Lihong V. Wang, California Institute of Technology (United States)


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