Share Email Print
cover

Journal of Biomedical Optics • new

Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis
Author(s): Wendy-Julie Madore; Etienne De Montigny; Andréanne Deschênes; Fouzi Benboujja; Mikaël Leduc; Anne-Marie Mes-Masson; Diane M. Provencher; Kurosh Rahimi; Caroline Boudoux; Nicolas Godbout
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

The majority of high-grade serous ovarian cancers is now believed to originate in the fallopian tubes. Therefore, current practices include the pathological examination of excised fallopian tubes. Detection of tumors in the fallopian tubes using current clinical approaches remains difficult but is of critical importance to achieve accurate staging and diagnosis. Here, we present an intraoperative imaging system for the detection of human fallopian tube lesions. The system is based on optical coherence tomography (OCT) to access subepithelial tissue architecture. To demonstrate that OCT could identify lesions, we analyzed 180 OCT volumes taken from five different ovarian lesions and from healthy fallopian tubes, and compared them to standard pathological review. We demonstrated that qualitative features could be matched to pathological conditions. We then determined the feasibility of intraluminal imaging of intact human fallopian tubes by building a dedicated endoscopic single-fiber OCT probe to access the mucosal layer inside freshly excised specimens from five patients undergoing prophylactic surgeries. The probe insertion into the lumen acquired images over the entire length of the tubes without damaging the mucosa, providing the first OCT images of intact human fallopian tubes.

Paper Details

Date Published: 20 July 2017
PDF: 10 pages
J. Biomed. Opt. 22(7) 076012 doi: 10.1117/1.JBO.22.7.076012
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Wendy-Julie Madore, Ecole Polytechnique de Montréal (Canada)
CRCHUM (Canada)
Institut du cancer de Montréal (Canada)
Etienne De Montigny, École Polytechnique Montréal (Canada)
CRCHUM (Canada)
Andréanne Deschênes, École Polytechnique Montréal (Canada)
Fouzi Benboujja, Ecole Polytechnique de Montréal (Canada)
Mikaël Leduc, Ecole Polytechnique de Montréal (Canada)
Anne-Marie Mes-Masson, CRCHUM (Canada)
Institut du cancer de Montréal (Canada)
Univ. de Montréal (Canada)
Diane M. Provencher, CRCHUM (Canada)
Institut du cancer de Montréal (Canada)
Univ. de Montréal (Canada)
Kurosh Rahimi, CRCHUM (Canada)
Institut du cancer de Montréal (Canada)
Caroline Boudoux, Ecole Polytechnique de Montréal (Canada)
Nicolas Godbout, Ecole Polytechnique de Montréal (Canada)


© SPIE. Terms of Use
Back to Top