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Journal of Biomedical Optics

Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection
Author(s): Mira Sibai; Carl Fisher; Israel Veilleux; Jonathan T. Elliott; Frederic Leblond; David W. Roberts; Brian C. Wilson
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Paper Abstract

5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for

Paper Details

Date Published: 11 July 2017
PDF: 10 pages
J. Biomed. Opt. 22(7) 076007 doi: 10.1117/1.JBO.22.7.076007
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Mira Sibai, Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Carl Fisher, Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Israel Veilleux, Univ. Health Network (Canada)
Jonathan T. Elliott, Thayer School of Engg at Dartmouth (United States)
Frederic Leblond, Ecole Polytechnique de Montréal (Canada)
David W. Roberts, Dartmouth Hitchcock Medical Ctr. (United States)
Brian C. Wilson, Univ. of Toronto (Canada)
Univ. Health Network (Canada)

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