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Journal of Biomedical Optics

Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
Author(s): George S. Liu; Jinkyung Kim; Brian E. Applegate; John S. Oghalai
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Paper Abstract

Diseases that cause hearing loss and/or vertigo in humans such as Meniere’s disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissner’s membrane from its normal position was measured in cochlear cross sections. We validated our computer-aided measurements with manual measurements and with trained observer labels. This approach allows for computer-aided detection of endolymphatic hydrops in mice, with test performance showing sensitivity of 91% and specificity of 87% using a running average of five measurements. These findings indicate that this approach is accurate and reliable for classifying endolymphatic hydrops and quantifying endolymph volume.

Paper Details

Date Published: 6 July 2017
PDF: 10 pages
J. Biomed. Opt. 22(7) 076002 doi: 10.1117/1.JBO.22.7.076002
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
George S. Liu, Stanford Univ. School of Medicine (United States)
Jinkyung Kim, Stanford Univ. School of Medicine (United States)
Brian E. Applegate, Texas A&M Univ. (United States)
John S. Oghalai, Stanford Univ. (United States)

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