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Journal of Biomedical Optics • Open Access

Photoacoustic imaging using genetically encoded reporters: a review
Author(s): Joanna Brunker; Junjie Yao; Jan Laufer; Sarah E. Bohndiek

Paper Abstract

Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visualizing dynamic cellular and molecular processes. This is an enticing prospect but brings with it challenges and limitations associated with generating and detecting different types of reporters. The purpose of this review is to compare existing PAI reporters and signal detection strategies, thereby offering a practical guide, particularly for the nonbiologist, to choosing the most appropriate reporter for maximum sensitivity in the biological and technological system of interest.

Paper Details

Date Published: 17 July 2017
PDF: 18 pages
J. Biomed. Opt. 22(7) 070901 doi: 10.1117/1.JBO.22.7.070901
Published in: Journal of Biomedical Optics Volume 22, Issue 7
Show Author Affiliations
Joanna Brunker, Univ. of Cambridge (United Kingdom)
Junjie Yao, Duke Univ. (United States)
Jan Laufer, Martin-Luther-Univ. Halle-Wittenberg (Germany)
Sarah E. Bohndiek, Univ. of Cambridge (United Kingdom)

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