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Journal of Biomedical Optics

Dynamic time warping-based averaging framework for functional near-infrared spectroscopy brain imaging studies
Author(s): Li Zhu; Laleh Najafizadeh
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Paper Abstract

We investigate the problem related to the averaging procedure in functional near-infrared spectroscopy (fNIRS) brain imaging studies. Typically, to reduce noise and to empower the signal strength associated with task-induced activities, recorded signals (e.g., in response to repeated stimuli or from a group of individuals) are averaged through a point-by-point conventional averaging technique. However, due to the existence of variable latencies in recorded activities, the use of the conventional averaging technique can lead to inaccuracies and loss of information in the averaged signal, which may result in inaccurate conclusions about the functionality of the brain. To improve the averaging accuracy in the presence of variable latencies, we present an averaging framework that employs dynamic time warping (DTW) to account for the temporal variation in the alignment of fNIRS signals to be averaged. As a proof of concept, we focus on the problem of localizing task-induced active brain regions. The framework is extensively tested on experimental data (obtained from both block design and event-related design experiments) as well as on simulated data. In all cases, it is shown that the DTW-based averaging technique outperforms the conventional-based averaging technique in estimating the location of task-induced active regions in the brain, suggesting that such advanced averaging methods should be employed in fNIRS brain imaging studies.

Paper Details

Date Published: 21 June 2017
PDF: 12 pages
J. Biomed. Opt. 22(6) 066011 doi: 10.1117/1.JBO.22.6.066011
Published in: Journal of Biomedical Optics Volume 22, Issue 6
Show Author Affiliations
Li Zhu, Rutgers, The State Univ. of New Jersey (United States)
Laleh Najafizadeh, Rutgers, The State Univ. of New Jersey (United States)


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