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Journal of Biomedical Optics

Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography
Author(s): Alex S. Huang; Akram Belghith; Anna Dastiridou; Vikas Chopra; Linda M. Zangwill; Robert N. Weinreb
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Paper Abstract

The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemm’s canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. A Bayesian Ridge method was used to approximate the location of the SC on infrared confocal laser scanning ophthalmoscopic images with a cross multiplication tool developed to initiate SC/CC detection automated through a fuzzy hidden Markov Chain approach. Automatic segmentation of SC and initial CC’s was manually confirmed by two masked graders. Outflow pathways detected by the segmentation algorithm were reconstructed into a 3-D representation of AHO. Overall, only <1% of images (5114 total B-scans) were ungradable. Automatic segmentation algorithm performed well with SC detection 98.3% of the time and <0.1% false positive detection compared to expert grader consensus. CC was detected 84.2% of the time with 1.4% false positive detection. 3-D representation of AHO pathways demonstrated variably thicker and thinner SC with some clear CC roots. Circumferential (360 deg), automated, and validated AHO detection of angle structures in the living human eye with reconstruction was possible.

Paper Details

Date Published: 15 June 2017
PDF: 7 pages
J. Biomed. Opt. 22(6) 066010 doi: 10.1117/1.JBO.22.6.066010
Published in: Journal of Biomedical Optics Volume 22, Issue 6
Show Author Affiliations
Alex S. Huang, Doheny Eye Institute (United States)
Doheny Eye Ctrs. (United States)
Akram Belghith, Hamilton Glaucoma Ctr. (United States)
Univ. of California, San Diego (United States)
Shiley Eye Institute (United States)
Anna Dastiridou, Doheny Eye Institute (United States)
Doheny Eye Ctrs. (United States)
Vikas Chopra, Doheny Eye Institute (United States)
Doheny Eye Ctrs. (United States)
Linda M. Zangwill, Univ. of California, San Diego (United States)
Shiley Eye Institute (United States)
Hamilton Glaucoma Ctr. (United States)
Robert N. Weinreb, Univ. of California, San Diego (United States)
Shiley Eye Institute (United States)
Hamilton Glaucoma Ctr. (United States)


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