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Journal of Biomedical Optics • Open Access

Colposcopic imaging using visible-light optical coherence tomography
Author(s): Lian Duan; Michael D. McRaven; Wenzhong Liu; Xiao Shu; Jianmin Hu; Cheng Sun; Ronald S. Veazey; Thomas J. Hope; Hao F. Zhang

Paper Abstract

High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6 - mm 2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

Paper Details

Date Published: 8 May 2017
PDF: 6 pages
J. Biomed. Opt. 22(5) 056003 doi: 10.1117/1.JBO.22.5.056003
Published in: Journal of Biomedical Optics Volume 22, Issue 5
Show Author Affiliations
Lian Duan, Northwestern Univ. (United States)
Michael D. McRaven, Northwestern Univ. (United States)
Wenzhong Liu, Northwestern Univ. (United States)
Xiao Shu, Northwestern Univ. (United States)
Jianmin Hu, Northwestern Univ. (United States)
Wuhan Univ. of Technology (China)
Cheng Sun, Northwestern Univ. (United States)
Ronald S. Veazey, Tulane Univ. Health Sciences (United States)
Thomas J. Hope, Northwestern Univ. (United States)
Hao F. Zhang, Northwestern Univ. (United States)

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