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Journal of Biomedical Optics

Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care
Author(s): Probir Kumar Sarkar; Sanchari Pal; Nabarun Polley; Rajarshi Aich; Aniruddha Adhikari; Animesh Halder; Subhananda Chakrabarti; Prantar Chakrabarti; Samir Kumar Pal
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Paper Abstract

Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact hemoglobin measurement at low-resource point-of-care settings in human subjects, independent of their skin color, age, and sex, by measuring the optical spectrum of the blood flowing in the vascular bed of the bulbar conjunctiva. We developed software on the LabVIEW platform for automatic data acquisition and interpretation by nonexperts. The device is calibrated by comparing the differential absorbance of light of wavelength 576 and 600 nm with the clinical hemoglobin level of the subject. Our proposed method is consistent with the results obtained using the current gold standard, the automated hematology analyzer. The proposed noncontact optical device for hemoglobin estimation is highly efficient, inexpensive, feasible, and extremely useful in low-resource point-of-care settings. The device output correlates with the different degrees of anemia with absolute and trending accuracy similar to those of widely used invasive methods. Moreover, the device can instantaneously transmit the generated report to a medical expert through e-mail, text messaging, or mobile apps.

Paper Details

Date Published: 16 May 2017
PDF: 9 pages
J. Biomed. Opt. 22(5) 055006 doi: 10.1117/1.JBO.22.5.055006
Published in: Journal of Biomedical Optics Volume 22, Issue 5
Show Author Affiliations
Probir Kumar Sarkar, S.N. Bose National Ctr. for Basic Sciences (India)
Sanchari Pal, Nil Ratan Sircar Medical College & Hospital (NRS) (India)
Nabarun Polley, S.N. Bose National Ctr. for Basic Sciences (India)
Rajarshi Aich, Medical College and Hospital, Kolkata (India)
Aniruddha Adhikari, S.N. Bose National Ctr. for Basic Sciences (India)
Animesh Halder, S.N. Bose National Ctr. for Basic Sciences (India)
Subhananda Chakrabarti, Indian Institute of Technology Bombay (India)
Prantar Chakrabarti, Nil Ratan Sircar Medical College & Hospital (NRS) (India)
Samir Kumar Pal, S.N. Bose National Ctr. for Basic Sciences (India)

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