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Journal of Biomedical Optics • Open Access • new

Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture

Paper Abstract

To detect small-scale changes in tissue with optical techniques, small sampling volumes and, therefore, short source–detector separations are required. In this case, reflectance measurements are not adequately described by the diffusion approximation. Previous studies related subdiffusive reflectance to γ or σ , which parameterize the phase function. Recently, it was demonstrated that σ predicts subdiffusive reflectance better than γ , and that σ becomes less predictive for lower numerical apertures (NAs). We derive and evaluate the parameter R p NA , which incorporates the NA of the detector and the integral of the phase function over the NA in the backward and forward directions. Monte Carlo simulations are performed for overlapping source/detector geometries for a range of phase functions, reduced scattering coefficients, NAs, and source/detector diameters. R p NA improves prediction of the measured reflectance compared to γ and σ . It is, therefore, expected that R p NA will improve derivation of optical properties from subdiffusive measurements.

Paper Details

Date Published: 22 May 2017
PDF: 4 pages
J. Biomed. Opt. 22(5) 050501 doi: 10.1117/1.JBO.22.5.050501
Published in: Journal of Biomedical Optics Volume 22, Issue 5
Show Author Affiliations
Anouk L. Post, Academisch Medisch Centrum (The Netherlands)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Henricus J. C. M. Sterenborg, Academisch Medisch Centrum (The Netherlands)
The Netherlands Cancer Institute (The Netherlands)
Dirk J. Faber, Academisch Medisch Centrum (The Netherlands)
Ton G. van Leeuwen, Academisch Medisch Centrum (The Netherlands)


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