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Journal of Biomedical Optics

Near-infrared angiography for critical limb ischemia in a diabetic murine model
Author(s): Missael Garcia; Mohamed A. Zayed; Kyoung-mi Park; Viktor Gruev
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Paper Abstract

Peripheral arterial disease (PAD) is a highly prevalent disease process that afflicts more than 20% of individuals with diabetes. Progression of PAD in the setting of diabetes can lead to critical limb ischemia (CLI), which is associated with increased risk of wounds, gangrene, and limb loss. Prompt noninvasive evaluation of limbs affected by PAD progression and CLI is currently limited. Here, we evaluate the utility of a custom-designed multispectral imaging system for fluorescence-based near-infrared angiography and compare it to the existing gold standard of laser-scanning Doppler perfusion assessments. Due to its higher resolution and fluorescence sensitivity, near-infrared angiography demonstrates a greater capacity to characterize altered dynamic arterial perfusion in a clinically relevant diabetic murine model for CLI. Furthermore, we demonstrate that our imaging system can accurately track arterial perfusion recovery over time following induced ischemia, and reveal unique phenotypic differences in the setting of diabetes.

Paper Details

Date Published: 18 April 2017
PDF: 8 pages
J. Biomed. Opt. 22(4) 046006 doi: 10.1117/1.JBO.22.4.046006
Published in: Journal of Biomedical Optics Volume 22, Issue 4
Show Author Affiliations
Missael Garcia, Washington Univ. (United States)
Mohamed A. Zayed, Washington Univ. School of Medicine in St. Louis (United States)
Veterans Affairs St. Louis Health Care System (United States)
Kyoung-mi Park, Washington University School of Medicine (United States)
Viktor Gruev, Univ. of Illinois at Urbana-Champaign (United States)

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