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Journal of Biomedical Optics • new

Real-time temperature monitoring with fiber Bragg grating sensor during diffuser-assisted laser-induced interstitial thermotherapy
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Paper Abstract

High-sensitivity temperature sensors have been used to validate real-time thermal responses in tissue during photothermal treatment. The objective of the current study was to evaluate the feasible application of a fiber Bragg grating (FBG) sensor for diffuser-assisted laser-induced interstitial thermotherapy (LITT) particularly to treat tubular tissue disease. A 600 - μ m core-diameter diffuser was employed to deliver 980-nm laser light for coagulation treatment. Both a thermocouple and a FBG were comparatively tested to evaluate temperature measurements in ex vivo liver tissue. The degree of tissue denaturation was estimated as a function of irradiation times and quantitatively compared with light distribution as well as temperature development. At the closer distance to a heat source, the thermocouple measured up to 41% higher maximum temperature than the FBG sensor did after 120-s irradiation (i.e., 98.7 ° C ± 6.1 ° C for FBG versus 131.0 ° C ± 5.1 ° C for thermocouple; p < 0.001 ). Ex vivo porcine urethra tests confirmed the real-time temperature measurements of the FBG sensor as well as consistently circumferential tissue denaturation after 72-s irradiation ( coagulation thickness = 2.2 ± 0.3    mm ). The implementation of FBG can be a feasible sensing technique to instantaneously monitor the temperature developments during diffuser-assisted LITT for treatment of tubular tissue structure.

Paper Details

Date Published: 20 April 2017
PDF: 10 pages
J. Biomed. Opt. 22(4) 045008 doi: 10.1117/1.JBO.22.4.045008
Published in: Journal of Biomedical Optics Volume 22, Issue 4
Show Author Affiliations
Ngot Thi Pham, Pukyong National Univ. (Republic of Korea)
Seul Lee Lee, Pukyong National Univ. (Korea, Republic of)
Suhyun Park, Chung-Ang Univ. (Korea, Republic of)
Yong Wook Lee, Pukyong National Univ. (Korea, Republic of)
Hyun Wook Kang, Pukyong National Univ. (Korea, Republic of)

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