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Journal of Biomedical Optics

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis
Author(s): Yung-Jhe Yan; Ting-Wei Huang; Nai-Lun Cheng; Yao-Fang Hsieh; Ming-Hsui Tsai; Jin-Chern Chiou; Jeng-Ren Duann; Yung-Jiun Lin; Chin-Siang Yang; Mang Ou-Yang
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Paper Abstract

Oral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer.

Paper Details

Date Published: 19 April 2017
PDF: 10 pages
J. Biomed. Opt. 22(4) 045007 doi: 10.1117/1.JBO.22.4.045007
Published in: Journal of Biomedical Optics Volume 22, Issue 4
Show Author Affiliations
Yung-Jhe Yan, National Chiao Tung Univ. (Taiwan)
Ting-Wei Huang, National Chiao Tung Univ. (Taiwan)
Nai-Lun Cheng, National Chiao Tung Univ. (Taiwan)
Yao-Fang Hsieh, National Central Univ. (Taiwan)
Ming-Hsui Tsai, China Medical Univ. (Taiwan)
Jin-Chern Chiou, National Chiao Tung Univ. (Taiwan)
China Medical Univ. (Taiwan)
Jeng-Ren Duann, China Medical Univ. (Taiwan)
Yung-Jiun Lin, China Medical Univ. (Taiwan)
Chin-Siang Yang, National Chiao Tung Univ. (Taiwan)
Mang Ou-Yang, National Chiao Tung Univ. (Taiwan)

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