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Journal of Biomedical Optics

Shape-based reconstruction for transrectal diffuse optical tomography monitoring of photothermal focal therapy of prostate cancer: simulation studies
Author(s): Robert A. Weersink; Sahil Chaudhary; Kenwrick Mayo; Jie He; Brian C. Wilson
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Paper Abstract

We develop and demonstrate a simple shape-based approach for diffuse optical tomographic reconstruction of coagulative lesions generated during interstitial photothermal therapy (PTT) of the prostate. The shape-based reconstruction assumes a simple ellipsoid shape, matching the general dimensions of a cylindrical diffusing fiber used for light delivery in current clinical studies of PTT in focal prostate cancer. The specific requirement is to accurately define the border between the photothermal lesion and native tissue as the photothermal lesion grows, with an accuracy of 1    mm , so treatment can be terminated before there is damage to the rectal wall. To demonstrate the feasibility of the shape-based diffuse optical tomography reconstruction, simulated data were generated based on forward calculations in known geometries that include the prostate, rectum, and lesions of varying dimensions. The only source of optical contrast between the lesion and prostate was increased scattering in the lesion, as is typically observed with coagulation. With noise added to these forward calculations, lesion dimensions were reconstructed using the shape-based method. This approach for reconstruction is shown to be feasible and sufficiently accurate for lesions that are within 4 mm from the rectal wall. The method was also robust for irregularly shaped lesions.

Paper Details

Date Published: 6 April 2017
PDF: 12 pages
J. Biomed. Opt. 22(4) 045004 doi: 10.1117/1.JBO.22.4.045004
Published in: Journal of Biomedical Optics Volume 22, Issue 4
Show Author Affiliations
Robert A. Weersink, Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Sahil Chaudhary, Univ. of Toronto (Canada)
Kenwrick Mayo, Univ. of Toronto (Canada)
Jie He, Univ. of Toronto (Canada)
Brian C. Wilson, Univ. Health Network (Canada)
Univ. of Toronto (Canada)

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