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Journal of Biomedical Optics

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy
Author(s): Kenneth J. Furdella; Russell S. Witte; Jonathan P. Vande Geest
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Paper Abstract

Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120    μ g / ml , and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis.

Paper Details

Date Published: 13 February 2017
PDF: 7 pages
J. Biomed. Opt. 22(4) 041016 doi: 10.1117/1.JBO.22.4.041016
Published in: Journal of Biomedical Optics Volume 22, Issue 4
Show Author Affiliations
Kenneth J. Furdella, Univ. of Pittsburgh (United States)
Russell S. Witte, The Univ. of Arizona College of Medicine (United States)
Jonathan P. Vande Geest, Univ. of Pittsburgh (United States)


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