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Journal of Biomedical Optics

In vivo photoacoustic imaging of blood vessels using a homodyne interferometer with zero-crossing triggering
Author(s): Jiao Lu; Yingzhe Gao; Zhenhe Ma; Hongxian Zhou; Ruikang K. Wang; Yi Wang
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Paper Abstract

We demonstrate a quasinoncontact photoacoustic imaging method using a homodyne interferometer with a long coherence length laser. The generated photoacoustic signal is detected by a system that is locked at its maximum sensitivity through the use of balanced detection and zero-crossing triggering. The balanced detector is substantially equalized, so its output is zero when the system reaches the maximum sensitivity. The synchronization approach is used to trigger the excitation and detection of the photoacoustic signal. The system is immune to ambient vibrations. A thin water layer on the sample surface is used to reduce the effect of the rough tissue surface. The performance of the system is demonstrated by in vivo imaging of the microvasculature in mouse ears.

Paper Details

Date Published: 2 March 2017
PDF: 6 pages
J. Biomed. Opt. 22(3) 036002 doi: 10.1117/1.JBO.22.3.036002
Published in: Journal of Biomedical Optics Volume 22, Issue 3
Show Author Affiliations
Jiao Lu, Northeastern Univ. at Qinhuangdao (China)
Yingzhe Gao, Northeastern Univ. at Qinhuangdao (China)
Zhenhe Ma, Northeastern Univ. at Qinhuangdao (China)
Hongxian Zhou, Northeastern Univ. at Qinhuangdao (China)
Ruikang K. Wang, Univ. of Washington (United States)
Yi Wang, Northeastern Univ. at Qinhuangdao (China)


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