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Journal of Biomedical Optics • new

Comparative study of shear wave-based elastography techniques in optical coherence tomography
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Paper Abstract

We compare five optical coherence elastography techniques able to estimate the shear speed of waves generated by one and two sources of excitation. The first two techniques make use of one piezoelectric actuator in order to produce a continuous shear wave propagation or a tone-burst propagation (TBP) of 400 Hz over a gelatin tissue-mimicking phantom. The remaining techniques utilize a second actuator located on the opposite side of the region of interest in order to create three types of interference patterns: crawling waves, swept crawling waves, and standing waves, depending on the selection of the frequency difference between the two actuators. We evaluated accuracy, contrast to noise ratio, resolution, and acquisition time for each technique during experiments. Numerical simulations were also performed in order to support the experimental findings. Results suggest that in the presence of strong internal reflections, single source methods are more accurate and less variable when compared to the two-actuator methods. In particular, TBP reports the best performance with an accuracy error <inline-formula< <mml:math display="inline" xmlns:mml=""< <mml:mrow< <mml:mo form="prefix"<<</mml:mo< <mml:mn<4.1</mml:mn< <mml:mo<%</mml:mo< </mml:mrow< </mml:math< </inline-formula<. Finally, the TBP was tested in a fresh chicken tibialis anterior muscle with a localized thermally ablated lesion in order to evaluate its performance in biological tissue.

Paper Details

Date Published: 30 March 2017
PDF: 17 pages
J. Biomed. Opt. 22(3) 035010 doi: 10.1117/1.JBO.22.3.035010
Published in: Journal of Biomedical Optics Volume 22, Issue 3
Show Author Affiliations
Fernando Zvietcovich, Univ. of Rochester (United States)
Jannick P. Rolland, Univ. of Rochester (United States)
Jianing Yao, Univ. of Rochester (United States)
Panomsak Meemon, Univ. of Rochester (United States)
Suranaree Univ. of Technology (Thailand)
Kevin J. Parker, Univ. of Rochester (United States)

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