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Journal of Biomedical Optics

Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins
Author(s): Brandon S. Nichols; Antonio Llopis; Gregory M. Palmer; Samuel S. McCachren; Ozlem Senlik; David Miller; Martin A. Brooke; Nan M. Jokerst; Joseph Geradts; Rachel Greenup; Nimmi Ramanujam
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Paper Abstract

We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [ μ s ( λ ) and μ a ( λ ) ] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x , y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 × 2    cm 2 area in 9    min . The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.

Paper Details

Date Published: 22 February 2017
PDF: 16 pages
J. Biomed. Opt. 22(2) 026007 doi: 10.1117/1.JBO.22.2.026007
Published in: Journal of Biomedical Optics Volume 22, Issue 2
Show Author Affiliations
Brandon S. Nichols, Duke Univ. (United States)
Antonio Llopis, Duke Univ. (United States)
Gregory M. Palmer, Duke Univ. School of Medicine (United States)
Samuel S. McCachren, Duke Univ. (United States)
Ozlem Senlik, Duke Univ. (United States)
David Miller, Duke Univ. (United States)
Martin A. Brooke, Duke Univ. (United States)
Nan M. Jokerst, Duke Univ. (United States)
Joseph Geradts, Duke Univ. Medical Ctr. (United States)
Rachel Greenup, Duke Univ. Medical Ctr. (United States)
Nimmi Ramanujam, Duke Univ. (United States)


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