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Journal of Biomedical Optics

Diffuse optical tomography reconstruction method using ultrasound images as prior for regularization matrix
Author(s): Murad Althobaiti; Hamed Vavadi; Quing Zhu
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Paper Abstract

Ultrasound-guided diffuse optical tomography (DOT) is a promising imaging technique that maps hemoglobin concentrations of breast lesions to assist ultrasound (US) for cancer diagnosis and treatment monitoring. The accurate recovery of breast lesion optical properties requires an effective image reconstruction method. We introduce a reconstruction approach in which US images are encoded as prior information for regularization of the inversion matrix. The framework of this approach is based on image reconstruction package “NIRFAST.” We compare this approach to the US-guided dual-zone mesh reconstruction method, which is based on Born approximation and conjugate gradient optimization developed in our laboratory. Results were evaluated using phantoms and clinical data. This method improves classification of malignant and benign lesions by increasing malignant to benign lesion absorption contrast. The results also show improvements in reconstructed lesion shapes and the spatial distribution of absorption maps.

Paper Details

Date Published: 2 February 2017
PDF: 9 pages
J. Biomed. Opt. 22(2) 026002 doi: 10.1117/1.JBO.22.2.026002
Published in: Journal of Biomedical Optics Volume 22, Issue 2
Show Author Affiliations
Murad Althobaiti, Univ. of Connecticut (United States)
Hamed Vavadi, Univ. of Connecticut (United States)
Quing Zhu, Washington Univ. in St. Louis (United States)

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