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Journal of Biomedical Optics • Open Access

Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography
Author(s): Pengxiao Zang; Gangjun Liu; Miao Zhang; Jie Wang; Thomas S. Hwang; David J. Wilson; David Huang; Dengwang Li; Yali Jia

Paper Abstract

We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system ( > 200    kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.

Paper Details

Date Published: 1 February 2017
PDF: 10 pages
J. Biomed. Opt. 22(2) 026001 doi: 10.1117/1.JBO.22.2.026001
Published in: Journal of Biomedical Optics Volume 22, Issue 2
Show Author Affiliations
Pengxiao Zang, Casey Eye Institute (United States)
Shandong Normal Univ. (China)
Gangjun Liu, Casey Eye Institute (United States)
Miao Zhang, Casey Eye Institute (United States)
Jie Wang, Casey Eye Institute (United States)
Thomas S. Hwang, Casey Eye Institute (United States)
David J. Wilson, Casey Eye Institute (United States)
David Huang, Casey Eye Institute (United States)
Dengwang Li, Shandong Normal Univ. (China)
Yali Jia, Casey Eye Institute (United States)


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