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Journal of Biomedical Optics

Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing
Author(s): Oxana Semyachkina-Glushkovskaya; Arkady Abdurashitov; Alexander Dubrovsky; Denis Bragin; Olga Bragina; Natalia Shushunova; Galina Maslyakova; Nikita Navolokin; Alla Bucharskaya; Valery Tuchind; Jürgen Kurths; Alexander Shirokov
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Paper Abstract

The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain. The blood–brain barrier (BBB) is a gatekeeper that strongly controls the movement of different molecules from the blood into the brain. We know the scenarios during the opening of the BBB, but there is extremely limited information on how the brain clears the substances that cross the BBB. Here, using the model of sound-induced opening of the BBB, we clearly show how the brain clears dextran after it crosses the BBB via the meningeal lymphatic vessels. We first demonstrate successful application of optical coherence tomography (OCT) for imaging of the lymphatic vessels in the meninges after opening of the BBB, which might be a new useful strategy for noninvasive analysis of lymphatic drainage in daily clinical practice. Also, we give information about the depth and size of the meningeal lymphatic vessels in mice. These new fundamental data with the applied focus on the OCT shed light on the mechanisms of brain clearance and the role of lymphatic drainage in these processes that could serve as an informative platform for a development of therapy and diagnostics of diseases associated with injuries of the BBB such as stroke, brain trauma, glioma, depression, or Alzheimer disease.

Paper Details

Date Published: 23 December 2017
PDF: 9 pages
J. Biomed. Opt. 22(12) 121719 doi: 10.1117/1.JBO.22.12.121719
Published in: Journal of Biomedical Optics Volume 22, Issue 12
Show Author Affiliations
Oxana Semyachkina-Glushkovskaya, Saratov State Univ. (Russia)
Arkady Abdurashitov, Saratov State Univ. (Russia)
Alexander Dubrovsky, Saratov State Univ. (Russian Federation)
Denis Bragin, The Univ. of New Mexico (United States)
Saratov State Univ. (Russian Federation)
Olga Bragina, The Univ. of New Mexico (United States)
Natalia Shushunova, Saratov State Univ. (Russian Federation)
Galina Maslyakova, Saratov State Medical Univ. (Russia)
Nikita Navolokin, Saratov State Univ. (Russian Federation)
Saratov State Medical Univ. (Russian Federation)
Alla Bucharskaya, Saratov State Medical Univ. (Russia)
Valery Tuchind, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Jürgen Kurths, Saratov State Univ. (Russian Federation)
Humboldt-Univ. zu Berlin (Germany)
Potsdam Institute for Climate Impact Research (Germany)
Alexander Shirokov, Saratov State Univ. (Russian Federation)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Saratov State Medical Univ. (Russian Federation)

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