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Journal of Biomedical Optics • new

Age, ocular magnification, and circumpapillary retinal nerve fiber layer thickness
Author(s): Mengyu Wang; Tobias Elze; Dian Li; Neda Baniasadi; Kerstin Wirkner; Toralf Kirsten; Joachim Thiery; Markus Löffler; Christoph Engel; Franziska G. Rauscher
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Paper Abstract

Optical coherence tomography (OCT) manufacturers graphically present circumpapillary retinal nerve fiber layer thickness (cpRNFLT) together with normative limits to support clinicians in diagnosing ophthalmic diseases. The impact of age on cpRNFLT is typically implemented by linear models. cpRNFLT is strongly location-specific, whereas previously published norms are typically restricted to coarse sectors and based on small populations. Furthermore, OCT devices neglect impacts of lens or eye size on the diameter of the cpRNFLT scan circle so that the diameter substantially varies over different eyes. We investigate the impact of age and scan diameter reported by Spectralis spectral-domain OCT on cpRNFLT in 5646 subjects with healthy eyes. We provide cpRNFLT by age and diameter at 768 angular locations. Age/diameter were significantly related to cpRNFLT on 89%/92% of the circle, respectively (pointwise linear regression), and to shifts in cpRNFLT peak locations. For subjects from age 42.1 onward but not below, increasing age significantly decreased scan diameter ( r = 0.28 , p < 0.001 ), which suggests that pathological cpRNFLT thinning over time may be underestimated in elderly compared to younger subjects, as scan diameter decrease correlated with cpRNFLT increase. Our detailed numerical results may help to generate various correction models to improve diagnosing and monitoring optic neuropathies.

Paper Details

Date Published: 23 December 2017
PDF: 19 pages
J. Biomed. Opt. 22(12) 121718 doi: 10.1117/1.JBO.22.12.121718
Published in: Journal of Biomedical Optics Volume 22, Issue 12
Show Author Affiliations
Mengyu Wang, Univ. Leipzig (Germany)
Schepens Eye Research Institute (United States)
Tobias Elze, Univ. Leipzig (Germany)
Schepens Eye Research Institute (United States)
Dian Li, Univ. Leipzig (Germany)
Schepens Eye Research Institute (United States)
Neda Baniasadi, Univ. Lepizig (Germany)
Schepens Eye Research Institute (United States)
Kerstin Wirkner, Univ. Leipzig (Germany)
Toralf Kirsten, Univ. Leipzig (Germany)
Joachim Thiery, Univ. Leipzig (Germany)
Markus Löffler, Univ. Leipzig (Germany)
Christoph Engel, Univ. Leipzig (Germany)
Franziska G. Rauscher, Univ. Leipzig (Germany)
Universitätsklinikum Leipzig (Germany)


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