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Journal of Biomedical Optics

Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle
Author(s): Tobias Elze; Neda Baniasadi; Qingying Jin; Hui Wang; Mengyu Wang
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Paper Abstract

Retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) is widely used in clinical practice to support glaucoma diagnosis. Clinicians frequently interpret peripapillary RNFLT areas marked as abnormal by OCT machines. However, presently, clinical OCT machines do not take individual retinal anatomy variation into account, and according diagnostic biases have been shown particularly for patients with ametropia. The angle between the two major temporal retinal arteries (interartery angle, IAA) is considered a fundamental retinal ametropia marker. Here, we analyze peripapillary spectral domain OCT RNFLT scans of 691 glaucoma patients and apply multivariate logistic regression to quantitatively compare the diagnostic bias of spherical equivalent (SE) of refractive error and IAA and to identify the precise retinal locations of false-positive/negative abnormality marks. Independent of glaucoma severity (visual field mean deviation), IAA/SE variations biased abnormality marks on OCT RNFLT printouts at 36.7%/22.9% of the peripapillary area, respectively. 17.2% of the biases due to SE are not explained by IAA variation, particularly in inferonasal areas. To conclude, the inclusion of SE and IAA in OCT RNFLT norms would help to increase diagnostic accuracy. Our detailed location maps may help clinicians to reduce diagnostic bias while interpreting retinal OCT scans.

Paper Details

Date Published: 15 December 2017
PDF: 11 pages
J. Biomed. Opt. 22(12) 121713 doi: 10.1117/1.JBO.22.12.121713
Published in: Journal of Biomedical Optics Volume 22, Issue 12
Show Author Affiliations
Tobias Elze, Schepens Eye Research Institute (United States)
Max-Planck-Institut für Mathematik in den Naturwissenschaften (Germany)
Neda Baniasadi, Schepens Eye Research Institute (United States)
Univ. of Massachusetts Lowell (United States)
Qingying Jin, Schepens Eye Research Institute (United States)
Jilin Univ. (China)
Hui Wang, Schepens Eye Research Institute (United States)
Jilin Univ. of Finance and Economics (China)
Mengyu Wang, Schepens Eye Research Institute (United States)

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