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Journal of Biomedical Optics • new

Power-controlled temperature guided retinal laser therapy
Author(s): Alexander Baade; Claus von der Burchard; Meike Lawin; Stefan Koinzer; Benedikt Schmarbeck; Kerstin Schlott; Yoko Miura; Johann Roider; Reginald Birngruber; Ralf Brinkmann
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Paper Abstract

Laser photocoagulation has been a treatment method for retinal diseases for decades. Recently, studies have demonstrated therapeutic benefits for subvisible effects. A treatment mode based on an automatic feedback algorithm to reliably generate subvisible and visible irradiations within a constant irradiation time is introduced. The method uses a site-individual adaptation of the laser power by monitoring the retinal temperature rise during the treatment using optoacoustics. This provides feedback to adjust the therapy laser power during the irradiation. The technique was demonstrated on rabbits in vivo using a 532-nm continuous wave Nd:YAG laser. The temperature measurement was performed with 523-nm Q-switched Nd:YLF laser pulses with 75-ns pulse duration at 1-kHz repetition rate. The beam diameter on the fundus was 200    μ m for both lasers, respectively. The aim temperatures ranged from 50°C to 75°C in 11 eyes of 7 rabbits. The results showed ophthalmoscopically invisible effects below 55°C with therapy laser powers over a wide range. The standard deviation for the measured temperatures ranged from 2.1°C for an aim temperature of 50°C to 4.7°C for 75°C. The ED50 temperature value for ophthalmoscopically visible lesions in rabbits was determined as 65.3°C. The introduced method can be used for retinal irradiations with adjustable temperature elevations.

Paper Details

Date Published: 21 November 2017
PDF: 11 pages
J. Biomed. Opt. 22(11) 118001 doi: 10.1117/1.JBO.22.11.118001
Published in: Journal of Biomedical Optics Volume 22, Issue 11
Show Author Affiliations
Alexander Baade, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Claus von der Burchard, Univ. Medizinische Ctr. Schleswig-Holstein (Germany)
Meike Lawin, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Stefan Koinzer, Univ. Medizinische Ctr. Schleswig-Holstein (Germany)
Benedikt Schmarbeck, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Kerstin Schlott, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Yoko Miura, Institut für Biomedizinische Optik, Univ. zu Lübeck (Germany)
Johann Roider, Univ. Medizinische Ctr. Schleswig-Holstein (Germany)
Reginald Birngruber, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Institut für Biomedizinische Optik, Univ. zu Lübeck (Germany)
Ralf Brinkmann, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Institut für Biomedizinische Optik, Univ. zu Lübeck (Germany)

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