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Journal of Biomedical Optics • new

X-ray luminescence computed tomography using a focused x-ray beam
Author(s): Wei Zhang; Michael C. Lun; Alex Anh-Tu Nguyen; Changqing Li
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Paper Abstract

Due to the low x-ray photon utilization efficiency and low measurement sensitivity of the electron multiplying charge coupled device camera setup, the collimator-based narrow beam x-ray luminescence computed tomography (XLCT) usually requires a long measurement time. We, for the first time, report a focused x-ray beam-based XLCT imaging system with measurements by a single optical fiber bundle and a photomultiplier tube (PMT). An x-ray tube with a polycapillary lens was used to generate a focused x-ray beam whose x-ray photon density is 1200 times larger than a collimated x-ray beam. An optical fiber bundle was employed to collect and deliver the emitted photons on the phantom surface to the PMT. The total measurement time was reduced to 12.5 min. For numerical simulations of both single and six fiber bundle cases, we were able to reconstruct six targets successfully. For the phantom experiment, two targets with an edge-to-edge distance of 0.4 mm and a center-to-center distance of 0.8 mm were successfully reconstructed by the measurement setup with a single fiber bundle and a PMT.

Paper Details

Date Published: 10 November 2017
PDF: 11 pages
J. Biomed. Opt. 22(11) 116004 doi: 10.1117/1.JBO.22.11.116004
Published in: Journal of Biomedical Optics Volume 22, Issue 11
Show Author Affiliations
Wei Zhang, Univ. of California, Merced (United States)
Michael C. Lun, Univ. of California, Merced (United States)
Alex Anh-Tu Nguyen, Univ. of California, Merced (United States)
Changqing Li, Univ. of California, Merced (United States)


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