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Journal of Biomedical Optics

Noncontact holographic detection for photoacoustic tomography
Author(s): Christian Buj; Michael Münter; Benedikt Schmarbeck; Jens Horstmann; Gereon Hüttmann; Ralf Brinkmann
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Paper Abstract

A holographic method for high-speed, noncontact photoacoustic tomography is introduced and evaluated. Relative changes of the object’s topography, induced by the impact of thermoelastic pressure waves, were determined at nanometer sensitivity without physical contact. The object’s surface was illuminated with nanosecond laser pulses and imaged with a high-speed CMOS camera. From two interferograms measured before and after excitation of the acoustic wave, surface displacement was calculated and then used as the basis for a tomographic reconstruction of the initial pressure caused by optical absorption. The holographic detection scheme enables variable sampling rates of the photoacoustic signal of up to 50 MHz. The total acquisition times for complete volumes with 230 MVoxel is far below 1 s. Measurements of silicone and porcine skin tissue phantoms with embedded artificial absorbers, which served as a model for human subcutaneous vascular networks, were possible. Three-dimensional reconstructions of the absorbing structures show details with a diameter of 310    μ m up to a depth of 2.5 mm. Theoretical limitations and the experimental sensitivity, as well as the potential for in vivo imaging depending on the detection repetition rate, are analyzed and discussed.

Paper Details

Date Published: 13 October 2017
PDF: 14 pages
J. Biomed. Opt. 22(10) 106007 doi: 10.1117/1.JBO.22.10.106007
Published in: Journal of Biomedical Optics Volume 22, Issue 10
Show Author Affiliations
Christian Buj, Univ. zu Lübeck (Germany)
Michael Münter, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Benedikt Schmarbeck, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Jens Horstmann, Medizinisches Laserzentrum Lübeck GmbH (Germany)
Univ. zu Köln (Germany)
Gereon Hüttmann, Univ. zu Lübeck (Germany)
Airway Research Ctr. North (ARCN) (Germany)
Ralf Brinkmann, Univ. zu Lübeck (Germany)
Medizinisches Laserzentrum Lübeck GmbH (Germany)

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