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Journal of Biomedical Optics • new

Toward jet injection by continuous-wave laser cavitation
Author(s): Carla Berrospe Rodríguez; Claas Willem Visser; Stefan Schlautmann; David Fernandez Rivas; Rubén Ramos-García
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Paper Abstract

This is a study motivated by the need to develop a needle-free device for eliminating major global healthcare problems caused by needles. The generation of liquid jets by means of a continuous-wave laser, focused into a light absorbing solution, was studied with the aim of developing a portable and affordable jet injector. We designed and fabricated glass microfluidic devices, which consist of a chamber where thermocavitation is created and a tapered channel. The growth of a vapor bubble displaces and expels the liquid through the channel as a fast traveling jet. Different parameters were varied with the purpose of increasing the jet velocity. The velocity increases with smaller channel diameters and taper ratios, whereas larger chambers significantly reduce the jet speed. It was found that the initial position of the liquid–air meniscus interface and its dynamics contribute to increased jet velocities. A maximum velocity of 94 ± 3    m / s for a channel diameter of D = 120    μ m , taper ratio n = 0.25 , and chamber length E = 200    μ m was achieved. Finally, agarose gel-based skin phantoms were used to demonstrate the potential of our devices to penetrate the skin. The maximum penetration depth achieved was 1    mm , which is sufficient to penetrate the stratum corneum and for most medical applications. A meta-analysis shows that larger injection volumes will be required as a next step to medical relevance for laser-induced jet injection techniques in general.

Paper Details

Date Published: 13 October 2017
PDF: 9 pages
J. Biomed. Opt. 22(10) 105003 doi: 10.1117/1.JBO.22.10.105003
Published in: Journal of Biomedical Optics Volume 22, Issue 10
Show Author Affiliations
Carla Berrospe Rodríguez, Instituto Nacional de Astrofísica, Óptica y Electrónica (México)
Claas Willem Visser, Wyss Institute for Biologically Inspired Engineering (United States)
Univ. Twente (Netherlands)
Stefan Schlautmann, Univ. Twente (The Netherlands)
David Fernandez Rivas, Univ. Twente (The Netherlands)
Rubén Ramos-García, Instituto Nacional de Astrofísica, Óptica y Electrónica (México)

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